Generic Name: mixed respiratory vaccine (MIXED RESP i ra tor ee VAK een)
Brand Names: MRV
What is MRV (mixed respiratory vaccine)?
Mixed respiratory vaccine is a mixture of killed bacteria. It is used to strengthen the immune system to help your body fight chronic infections.
Mixed respiratory vaccine is used in people with chronic infections such as infectious asthma, chronic sinusitis (inflamation of the sinuses), nasal polyps, ear infections, and other upper respiratory tract infections.
The vaccine works by exposing you to a small dose of the bacteria mixture, which causes the body to develop immunity to certain diseases. This vaccine will not treat an active infection that has already developed in the body.
Like any vaccine, the mixed respiratory vaccine may not provide protection from disease in every person.
What is the most important information I should know about MRV (mixed respiratory vaccine)?
You should not receive this vaccine if have rheumatoid arthritis, systemic lupus erythematosus (SLE), or any other connective tissue disorders such as Marfan syndrome, Ehlers-Danlos syndrome, osteogenesis imperfecta, or scleroderma.
Before receiving mixed respiratory vaccine, tell your doctor if you have diabetes or eczema.
The mixed respiratory vaccine is usually given every several days. The first shot is usually given at a larger dose. The booster shots are then given at gradually smaller doses as your body begins to respond to the vaccine. After several months, your shots may be spaced farther apart, or you may need them only every other week.
The vaccine works by exposing you to a small dose of a bacteria mixture, which causes the body to develop immunity to certain diseases. This vaccine will not treat an active infection that has already developed in the body.
What should I discuss with my healthcare provider before receiving this vaccine?
You should not receive this vaccine if have:
rheumatoid arthritis;
lupus erythematosus (SLE); or
other connective tissue disorders such as Marfan syndrome, Ehlers-Danlos syndrome, osteogenesis imperfecta, or scleroderma.
Before receiving this vaccine, tell your doctor if you have:
diabetes; or
eczema.
You can still receive a vaccine if you have a cold or fever. In the case of a more severe illness with a fever or any type of infection, wait until you get better before receiving this vaccine.
FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether mixed respiratory vaccine passes into breast milk. Do not receive this vaccine without telling your doctor if you are breast-feeding a baby.
How should I use MRV (mixed respiratory vaccine)?
This vaccine is given as an injection (shot) under the skin. You will receive this injection in a doctor's office or other clinic setting.
The mixed respiratory vaccine is usually given every several days. The first shot is usually given at a larger dose. The booster shots are then given at gradually smaller doses as your body begins to respond to the vaccine. After several months, your shots may be spaced farther apart, or you may need them only every other week.
Your individual vaccination schedule may be different from these guidelines. Follow your doctor's instructions.
Your doctor may recommend treating fever and pain with an aspirin-free pain reliever such as acetaminophen (Tylenol) or ibuprofen (Motrin, Advil, and others) when the shot is given and for the next 24 hours. Follow the label directions or your doctor's instructions about how much of this medicine to take.
It is especially important to prevent fever from occurring if you have a seizure disorder such as epilepsy.
What happens if I miss a dose?
Contact your doctor if you will miss a booster dose or if you get behind schedule. The next dose should be given as soon as possible. There is no need to start over.
Be sure you receive all recommended doses of this vaccine. If you do not receive the full series of vaccines, you may not be fully protected against the disease.
What happens if I overdose?
An overdose of this vaccine is unlikely to occur.
What should I avoid while using MRV (mixed respiratory vaccine)?
Do not receive a "live" vaccine such as measles, mumps, rubella (MMR), oral polio, yellow fever, or varicella (chickenpox) for at least 4 weeks after you have received the mixed respiratory vaccine. The other live vaccine may not work as well during this time, and may not fully protect you from disease.
MRV (mixed respiratory vaccine) side effects
You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot. Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
severe skin rash, itching, or swelling;
a feeling of extreme discomfort or uneasiness;
severe muscle pain; or
high fever (within a few hours or a few days after the vaccine).
Less serious side effects include:
redness, pain, swelling, or a lump where the shot was given;
minor aches and pains;
drowsiness; or
mild skin rash.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
What other drugs will affect MRV (mixed respiratory vaccine)?
Before receiving this vaccine, tell the doctor about all other vaccines you have recently received.
Also tell the doctor if you have recently received drugs or treatments that can weaken the immune system, including:
an oral, nasal, inhaled, or injectable steroid medicine;
medications to treat psoriasis, rheumatoid arthritis, or other autoimmune disorders, such as azathioprine (Imuran), efalizumab (Raptiva), etanercept (Enbrel), leflunomide (Arava), and others; or
medicines to treat or prevent organ transplant rejection, such as basiliximab (Simulect), cyclosporine (Sandimmune, Neoral, Gengraf), muromonab-CD3 (Orthoclone), mycophenolate mofetil (CellCept), sirolimus (Rapamune), or tacrolimus (Prograf).
If you are using any of these medications, you may not be able to receive the vaccine, or may need to wait until the other treatments are finished.
There may be other drugs that can affect this vaccine. Tell your doctor about all the prescription and over-the-counter medications you have received. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
More MRV resources
- MRV Drug Interactions
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- Respiratory Tract Disease
Where can I get more information?
- Your doctor or pharmacist may have information about this vaccine written for health professionals that you may read. You may also find additional information from your local health department or the Centers for Disease Control and Prevention.
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